Document and Entity Information [Abstract] Document And Entity Information [Abstract] Entity Registrant Name Entity Central Index Key Document Type Document Period End Date Amendment Flag Current Fiscal Year End Date Entity Filer Category Entity Common Stock, Shares Outstanding Document Fiscal Year Focus Document Fiscal Period Focus Condensed Consolidated Balance Sheets [Abstract] Assets [Abstract] ASSETS Prepaid Expense and Other Assets, Current Prepaid expenses and other current assets Assets, Current Total current assets Long-term Investments Long-term investments Property, Plant and Equipment, Net Property and equipment, net Other Assets, Noncurrent Other non-current assets Assets Total assets Accounts Payable, Current Accounts payable Employee-related Liabilities, Current Accrued compensation and related benefits Accrued Liabilities, Current Other accrued liabilities Deferred Revenue, Current Deferred revenue, current portion Outstanding balance under long-term loan agreement, current portion Long-term Debt, Current Maturities Long-term debt, current portion Liabilities, Current Total current liabilities Long-term Debt, Excluding Current Maturities Long-term debt, net of current portion Deferred Revenue, Noncurrent Deferred revenue, net of current portion Other Liabilities, Noncurrent Other non-current liabilities Liabilities Total liabilities Commitments and Contingencies Commitments and contingencies Stockholders' Equity Attributable to Parent [Abstract] Stockholders' equity: Additional Paid in Capital Additional paid-in capital Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive loss Retained Earnings (Accumulated Deficit) Accumulated deficit Stockholders' Equity Attributable to Parent Total stockholders' equity Liabilities and Equity Total liabilities and stockholders' equity Allowance for Doubtful Accounts Receivable, Current Accounts receivable, allowances Common Stock, Par or Stated Value Per Share Common stock, par value Common Stock, Shares Authorized Common stock, shares authorized Common Stock, Shares, Outstanding Common stock, shares outstanding Condensed Consolidated Statements of Operations and Comprehensive Loss [Abstract] Revenues [Abstract] Revenue: Sales Revenue, Goods, Net Total Product revenue License and Collaboration Revenue License and collaboration revenue License and collaboration revenue. Revenue from Grants Grant revenue Revenues Total revenue Costs and Expenses [Abstract] Costs and expenses: Cost of Goods Sold Cost of product revenue Research and Development Expense Research and development Selling, General and Administrative Expense Selling, general and administrative Costs and Expenses Total costs and expenses Operating Income (Loss) Loss from operations Interest Expense Interest expense Gain from Extinguishment of Convertible Preferred Stock Warrants Gain from extinguishment of convertible preferred stock warrants Gain from extinguishment of convertible preferred stock warrants Gain from extinguishment of convertible preferred stock warrants. Other Nonoperating Income (Expense) Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Extraordinary Items, Noncontrolling Interest Loss before income taxes Income Tax Expense (Benefit) Provision for income taxes Net Income (Loss) Attributable to Parent Net loss Net loss Preferred Stock Dividends and Other Adjustments Deemed dividend related to the change in conversion rate of Series E ' convertible preferred stock Deemed dividend Net Income (Loss) Available to Common Stockholders, Diluted Net loss attributed to common stockholders Earnings Per Share, Basic and Diluted Net loss per share attributed to common stockholders, basic and diluted Comprehensive Income, Net of Tax, Attributable to Parent Comprehensive loss Condensed Consolidated Statements of Cash Flows [Abstract] Net Cash Provided by (Used in) Operating Activities [Abstract] Operating activities Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Depreciation, Amortization and Accretion, Net Depreciation and amortization Share-based Compensation Stock-based compensation expense Write Off of Debt Discount upon Note Repayment Write-off of debt discount upon note repayment Write-off of debt discount upon note repayment. Amortization of Debt Discount (Premium) Amortization of debt discount and issuance cost Gain (Loss) on Sale of Property Plant Equipment Loss on disposal of property and equipment Increase (Decrease) in Operating Capital [Abstract] Changes in assets and liabilities: Increase (Decrease) in Accounts Receivable Accounts receivable Increase (Decrease) in Inventories Inventories Increase (Decrease) in Prepaid Expense and Other Assets Prepaid expenses and other assets Increase (Decrease) in Accounts Payable Accounts payable Increase (Decrease) in Deferred Revenue Deferred revenue Increase (Decrease) in Other Operating Liabilities Other liabilities Net Cash Provided by (Used in) Operating Activities Net cash used in operating activities Net Cash Provided by (Used in) Investing Activities [Abstract] Investing activities Payments to Acquire Investments Purchases of investments Proceeds from Sale, Maturity and Collection of Investments Proceeds from sales and maturities of investments Payments to Acquire Property, Plant, and Equipment Purchases of property and equipment Net Cash Provided by (Used in) Financing Activities [Abstract] Financing activities Proceeds from Issuance Initial Public Offering Proceeds from initial public offering, net of issuance costs Proceeds from Stock Options Exercised Proceeds from exercise of stock options Proceeds from Notes Payable Proceeds from note Subordinated secured promissory notes issued Repayments of Notes Payable Repayment of note Repayments of Long-term Lines of Credit Repayment of line of credit Net Cash Provided by (Used in) Financing Activities Net cash (used in) provided by financing activities Effect of Exchange Rate on Cash and Cash Equivalents Effect of foreign exchange rate fluctuations on cash and cash equivalents Cash and Cash Equivalents, Period Increase (Decrease) Net (decrease) increase in cash and cash equivalents Noncash Investing and Financing Items [Abstract] Non-cash investing and financing activities Conversion Of Convertible Preferred Stock To Common Stock Upon Initial Public Offering Conversion of convertible preferred stock to common stock upon initial public offering Conversion of convertible preferred stock to common stock upon initial public offering. Issuance of Convertible Preferred Stock Warrants in Connection with Note and Warrant Agreement Issuance of convertible preferred stock warrants in connection with note and warrant agreement and long-term debt Issuance of convertible preferred stock warrants in connection with note and warrant agreement and long-term debt. Issuances Extinguishment of Convertible Preferred Stock Warrants upon IPO Extinguishment of convertible preferred stock warrants Extinguishment of convertible preferred stock warrants upon initial public offering Extinguishment of convertible preferred stock warrants upon IPO. Conversion of Convertible Preferred Stock Warrants to Common Stock Warrants Conversion to common stock warrants Conversion of convertible preferred stock warrants to common stock warrants Conversion of convertible preferred stock warrants to common stock warrants. Issuance of Common Stock in Connection with Net Exercise of Warrants Exercises Issuance of common stock in connection with net exercise of convertible preferred stock warrants Issuance of common stock in connection with net exercise of warrants. Description of Business [Abstract] Description of Business Nature of Operations [Text Block] Summary of Significant Accounting Policies [Abstract] Summary of Significant Accounting Policies Significant Accounting Policies [Text Block] License And Collaboration Agreements [Text Block] License, Collaboration and Grant Agreements The entire disclosure of license and collaboration agreements. Inventories [Abstract] Inventory Disclosure [Text Block] Inventories Fair Value of Financial Instruments [Abstract] Fair Value of Financial Instruments Fair Value Disclosures [Text Block] Note and Warrant Purchase Agreement 2011 [Abstract] Long-Term Debt [Abstract] Long-term Debt [Text Block] Long-Term Debt Line of Credit [Abstract] Convertible Preferred Stock Warrants [Abstract] Convertible Preferred Stock Warrants Disclosure [Text Block] Convertible Preferred Stock Warrants The entire disclosure of convertible preferred stock warrants. Stock-Based Compensation [Abstract] Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Stock-Based Compensation Income Taxes [Abstract] Income Tax Disclosure [Text Block] Income Taxes Amended And Restated Certificate Of Incorporation [Policy Text Block] Amended and Restated Certificate of Incorporation The entire policy disclosure for amended and restated certificate of incorporation . Initial Public Offering [Policy Text Block] Initial Public Offering The policy disclosure for initial public offering. Legal Matters [Policy Text Block] Legal Matters The entire policy disclosure for legal matters. Basis of Accounting, Policy [Policy Text Block] Basis of Presentation Earnings Per Share, Policy [Policy Text Block] Net Loss per Share Attributed to Common Stockholders Comprehensive Income, Policy [Policy Text Block] Comprehensive Loss Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] Assets measured at fair value by level within the fair value hierarchy Income Taxes (Textual) [Abstract] Income Taxes (Textual) [Abstract] Income taxes. Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate Difference between provision or benefit for income taxes for the periods from the U.S. Federal statutory rate Fair Value, Inputs, Level 2 [Member] Level II [Member] Money Market Funds [Member] Money market funds [Member] Assets, Fair Value Disclosure Total assets measured at fair value Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table] Fair Value By Fair Value Hierarchy Level [Axis] Fair Value Measurements Fair Value Hierarchy [Domain] Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation By Asset Class [Domain] Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Line Items] Available-for-sale Securities, Gross Unrealized Losses Gross Unrealized Loss Available-for-sale Securities, Gross Unrealized Gains Gross Unrealized Gain Fair Value of Financial Instruments (Textual) [Abstract] Fair value of financial instruments. Fair Value of Financial Instruments (Textual) [Abstract] Subordinated Secured Promissory Notes [Member] Subordinated secured promissory notes [Member] Subordinated secured promissory notes. Common Stock [Member] Common stock [Member] Convertible Preferred Stock [Member] Convertible preferred stock [Member] Note and Warrant Purchase Agreement Two Thousand Eleven (Textual) [Abstract] Note and Warrant Purchase Agreement 2011 (Textual) [Abstract] Note and warrant purchase agreement two thousand eleven. Warrants Not Settleable in Cash, Fair Value Disclosure Fair value of warrants Debt Instrument, Unamortized Discount Unamortized discount recognized as interest expense Short-term Debt, Type [Axis] Short-term Debt, Type [Domain] Class of Warrant or Right [Table] Class of Warrant or Right [Line Items] Long Term Debt (Textual) [Abstract] Long-Term Debt (Textual) [Abstract] Long Term debt. Line of Credit (Textual) [Abstract] Line of credit. Line of Credit (Textual) [Abstract] Term of Contractual Agreement Include Line of Credit Facility Term of line of credit agreement Term of contractual agreement include line of credit facility. Line of Credit Facility, Amount Outstanding Outstanding balance on the Line of Credit Debt Instrument, Basis Spread on Variable Rate Additional interest rate Line of Credit Facility, Maximum Borrowing Capacity Maximum ability to borrow under Line of Credit JAPAN Japan [Member] UNITED STATES United States [Member] Convertible Preferred Stock Warrants (Textual) [Abstract] Convertible preferred stock warrants. Convertible Preferred Stock Warrants (Textual) [Abstract] Class of Stock [Axis] Class of Stock [Domain] Schedule of Revenues from External Customers and Long-Lived Assets [Table] Geographical [Axis] Segment, Geographical [Domain] Revenues from External Customers and Long-Lived Assets [Line Items] Description of Business (Textual) [Abstract] Description of Business (Textual) [Abstract] Description of business. Date of Incorporation of Company Incorporation of the company Date of incorporation of the company. Date of Reincorporation of Company Reincorporation of the company Date of reincorporation of the company. Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Summary of Significant Accounting Policies (Textual) [Abstract] Summary of Significant Accounting Policies (Textual) [Abstract] Summary of significant accounting policies. Proceeds from Issuance of Common Stock Net cash proceeds received Stock Issued During Period, Shares, Conversion of Convertible Securities Conversion of outstanding shares of convertible preferred stock Stock Issued During Period, Value, Conversion of Convertible Securities Related carrying value of conversion Stock Based Compensation (Textual) [Abstract] Stock-Based Compensation (Textual) [Abstract] Stock based compensation. Stock Based Compensation (Additional Textual) [Abstract] Stock-Based Compensation (Additional Textual) [Abstract] Stock based compensation. Exercise Price One [Member] Exercise price one [Member] Exercise price. Exercise Price Two [Member] Exercise price two [Member] Exercise price. Exercise Price Three [Member] Exercise price three [Member] Exercise price. Exercise Price Four [Member] Exercise price four [Member] Exercise price. Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross Employee stock options granted Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period Vesting period of the grant date fair value Employee Service Share-based Compensation, Nonvested Awards, Total Compensation Cost Not yet Recognized Unrecognized stock-based compensation costs Employee Service Share-based Compensation, Nonvested Awards, Total Compensation Cost Not yet Recognized, Period for Recognition Expected weighted average period Schedule of Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Table] Exercise Price Range [Axis] Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Domain] Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items] Stock Options [Member] Stock Options [Member] Antidilutive Securities Excluded from Computations of Earnings Per Share [Abstract] Summary of potential common shares were excluded from the computation of diluted net loss per share attributed to common stockholders Anti-dilutive securities excluded from computations of earnings per share. Convertible Preferred Stock Conversion Price Before Amendment Conversion price of our Series E convertible preferred stock before Amendment Convertible preferred stock conversion price before amendment. Convertible Preferred Stock Conversion Price After Amendment Conversion price of our Series E convertible preferred stock after Amendment Convertible preferred stock conversion price after amendment. Stock Issued During Period, Shares, New Issues Sale of common stock shares Loss Contingency Accrual, at Carrying Value Accrual of amounts Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Options to purchase common stock Proceeds from Customers for Upfront Payments Up-front payment received Received additional amount under collaboration agreement Proceeds from customers for upfront payments. Inventory, Raw Materials, Net of Reserves Raw materials Inventory, Work in Process, Net of Reserves Work-in-process Inventory, Finished Goods, Net of Reserves Finished goods Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Antidilutive Securities [Axis] Antidilutive Securities, Name [Domain] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Assets, Current [Abstract] Current assets: Liabilities, Current [Abstract] Current liabilities: Other Geographical Countries [Member] Other [Member] Other geographical countries. Segment, Geographical, Groups of Countries, Group One [Member] Europe [Member] Segment, Geographical, Groups of Countries, Group Two [Member] Asia Pacific [Member] Stock Granted During Period, Value, Share-based Compensation, Gross Total grant date fair value Allocated Share-based Compensation Expense Stock-based compensation expense Weighted Average Number of Shares Outstanding, Basic and Diluted Shares used in computing net loss per share attributed to common stockholders, basic and diluted Schedule of Cash and Cash Equivalents [Table Text Block] Summary of cash and cash equivalents Available-for-sale Securities [Table Text Block] Summary of investments Fair Value, Inputs, Level 1 [Member] Level I [Member] Fair Value, Inputs, Level 3 [Member] Level III [Member] Fair Value Liabilities Measured on Recurring Basis Unobservable Input Reconciliation [Abstract] Summary of changes in the value of convertible preferred stock warrants Fair value liabilities measured on recurring basis unobservable input reconciliation. Available-for-sale Debt Securities, Amortized Cost Basis Amortized Cost Available-for-sale Securities, Debt Securities Estimated Fair Value Available-for-sale Securities [Abstract] Summary of investments Assets, Fair Value Disclosure [Abstract] Assets Cash Equivalents, at Carrying Value Cash Equivalents At Carrying Value Cash and Cash Equivalents, at Carrying Value [Abstract] Summary of cash and cash equivalents Line of Credit Facility, Interest Rate Description Interest rate description Line of Credit Facility, Interest Rate During Period Interest rate, first among the two described rate Debt Instrument Additional Payment Principal Additional principal payment Debt instrument additional payment principal. Debt Instrument, Periodic Payment Principal and interest payments per month Long Term Debt (Additional Textual) [Abstract] Long-Term Debt (Additional Textual) [Abstract] Long-term debt. Convertible Preferred Stock Warrants (Additional Textual) [Abstract] Convertible preferred stock warrants. Convertible Preferred Stock Warrants (Additional Textual) [Abstract] Number Of Shares Exercised Under Warrants Net warrants exercised for shares Number of shares exercised under warrants. Gain From Extinguishment of Convertible Preferred Stock Warrant Liability related to unexercised warrants recognized as gain from extinguishment of convertible preferred stock warrants Gain from extinguishment of convertible preferred stock warrants. Conversion of Convertible Preferred Stock Warrants to Common Stock Warrants Number of Share Warrants issued to acquire shares converted Warrants to purchase shares converted Conversion of convertible preferred stock warrants to common stock warrants number of share. Adjustments to Additional Paid in Capital Conversion of Convertible Preferred Stock Warrants to Common Stock Warrants Warrants issued reclassified to additional paid-in capital Adjustments to additional paid in capital conversion of convertible preferred stock warrants to common stock warrants. Asset Class [Axis] Schedule of Available-for-sale Securities [Table] Major Types of Debt and Equity Securities [Axis] Major Types of Debt and Equity Securities [Domain] Schedule of Cash and Cash Equivalents [Table] Cash and Cash Equivalents [Axis] Cash and Cash Equivalents [Domain] Cash and Cash Equivalents [Line Items] Cash Warrant [Member] Warrants [Member] Convertible Preferred Stock Under Warrant Shares Expired Unexercised Convertible preferred stock under warrant shares expired unexercised. Convertible preferred stock under warrant shares expired unexercised. Debt Instrument, Interest Rate, Stated Percentage Subordinated secured promissory notes, interest rate Debt Instrument, Maturity Date Debt maturity date Range [Axis] Minimum [Member] Minimum [Member] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Abstract] Assets measured at fair value by level within the fair value hierarchy Fair Value, Measurement with Unobservable Inputs Reconciliations, Recurring Basis, Liability Value Fair value as of June 30, 2011 Fair value as of December 31, 2010 Minimum Contractual Maturity Period of Remaining Investments Contractual maturity dates of remaining investments. Contractual maturity dates of remaining investments Debt Instrument Maturity Month Extended maturity date Debt instrument maturity month. Line of Credit, Current Line of credit License and Collaboration Agreements [Abstract] License, Collaboration and Grant Agreements [Abstract] License and collaboration agreements. License and Collaboration Agreements (Textual) [Abstract] License and collaboration agreements. License and Collaboration Agreements (Textual) [Abstract] Financing [Axis] Financing [Domain] Proceeds from Lines of Credit Proceeds from line of credit Repayments of Long-term Debt Repayment of long-term debt Partial paydown of principal in the amount Segment Reporting Disclosure [Text Block] Information About Geographic Areas Note and Warrant Purchase Agreement Two Thousand Eleven Disclosure [Text Block] Note and warrant purchase agreement 2011. Note and Warrant Purchase Agreement 2011 US Government and Government Agencies and Authorities [Member] U.S. government and agency securities [Member] Class of Warrant or Right, Exercise Price of Warrants or Rights Warrants issued to acquire shares, price per share Exercise price of warrants Repayment of Debt [Member] Repayment of Debt [Member] Fair Value, Liabilities Measured on Recurring Basis, Gain (Loss) Included in Other Income Loss from changes in the fair value of convertible preferred stock warrants Loss from changes in the fair value of convertible preferred stock warrants Schedule of Revenue from External Customers and Long-Lived Assets, by Geographical Areas [Table Text Block] Product revenue by geography based on the billing address of our customers Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block] Summary of changes in the value of convertible preferred stock warrants Long-term Debt, Fair Value Fair value of long-term debt Available-for-sale Securities, Debt Maturities, Next Rolling Twelve Months, Fair Value Value of investments within one year Minimum Contractual Maturity Period Part of Investments Contractual maturity period of investments Minimum contractual maturity period part of investments. Series E One Convertible Preferred Stock [Member] Series E-1 Convertible preferred stock [Member] Series E-1 convertible preferred stock. Range [Domain] Summary of potential common shares were excluded from the computation of diluted net loss per share attributed to common stockholders License and Agreements with Potential Future Milestones Number Agreements with potential future milestones License and agreements with potential future milestones number. Fair Value of Financial Instruments (Additional Textual) [Abstract] Fair value of financial instruments. Fair Value Inputs, Assets, Quantitative Information [Table] Maximum [Member] Fair Value Inputs, Assets, Quantitative Information [Line Items] Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Exercise price of options granted Sales Revenue, Goods, Net [Abstract] Product revenue by geography based on the billing address of our customers Cash and Cash Equivalents, at Carrying Value Cash and cash equivalents at end of period Cash and cash equivalents at beginning of period Cash and cash equivalents Cash and cash equivalents Short-term Investments Short-term investments Liabilities and Equity [Abstract] LIABILITIES AND STOCKHOLDERS' EQUITY Other income (expense), net Line of Credit Text Block Line of credit. Line of Credit Information About Geographic Areas [Abstract] Litigation Litigation settlement Litigation. Common Shares Issued Net Exercise of Warrants Shares issued on exercise of warrants The number of common shares issued upon the net exercise of warrants. Increase In Fair Value of Warrants Increase in fair value of warrants. Increase in fair value of warrants Class of Warrant or Right, Number of Securities Called by Warrants or Rights Convertible preferred stock that had been granted at various times Warrants for Shares Exercised Reclassified to Additional Paid in Capital Warrants for shares exercised reclassified to additional paid-in capital. Warrants for shares exercised reclassified to additional paid-in capital Common Stock, Shares, Issued Common stock, shares issued Warrants issued to acquire shares Accounts Receivable, Net, Current Accounts receivable (net of allowances of $375 and $366 at June 30, 2012 and December 31, 2011, respectively) Common Stock, Value, Issued Common stock: $0.001 par value, 200,000 shares authorized at June 30, 2012 and December 31, 2011; 20,633 and 20,231 shares issued and outstanding as of June 30, 2012 and December 31, 2011, respectively Increase (Decrease) in Restricted Cash Increase in restricted cash Net Cash Provided by (Used in) Investing Activities Net cash provided by (used in) investing activities Exercisable Term from the Agreement Exercisable term from the agreements. Exercisable term from the agreements Schedule of License Collaboration and Grant Agreements [Table] Schedule of License Collaboration and Grant Agreements [Table] Schedule of license collaboration and grant agreements. Patent Litigation Patent litigation. Patent litigation Exercised Option Exercised our option and paid Life exercised option. Amortized to Selling General and Administrative Expense Amortized to selling general and administrative expense. Amortized to selling general and administrative expense Amortized to Cost of Product Revenue on Straight Line Base Payments for amortized to cost of product revenue Amortized to cost of product revenue on straight line base. License and Collaboration Agreements (Additional Textual) [Abstract] License and collaboration agreements. License and Collaboration Agreements (Additional Textual) [Abstract] Grant Awarded Grant awarded Grant awarded. Earning period Earning period. Earning period First Grant [Member] First grant. First Grant [Member] Second Grant [Member] Second grant. Second Grant [Member] License Collaboration and Grant Agreement [Line Items] License Collaboration and Grant Agreement [Line Items] License collaboration and grant agreement. Schedule of Inventory, Current [Table Text Block] Summary of Inventories Inventory, Net [Abstract] Summary of Inventories Inventory, Net Total Inventories Inventories Line of Credit Facility, Interest Rate at Period End Interest rate Payment For License Upfront Fees Payment for license upfront fees Payment for license upfront fees. Payment For License Extension Upfront Fees Payment for license extension upfront fees Payment for license extension upfront fees.